SeniorCarePharmacist.com: Helping You Make the Best Use of Your Medicines

Medications that should be avoided, if possible,
when certain diseases are present

Seek the advice of your pharmacist and/or physician
before making any changes to your medication regimen.

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DISEASE/ CONDITION

MEDICATIONS

ALERT

Heart Failure

Disopyramide (Norpace®, Norpace CR®)

May weaken the pumping of the heart and may worsen heart failure.

medications with high salt (sodium) content

May lead to water retention, which may worsen heart failure.

Diabetes

beta blockers (Tenormin®, Inderal®, Lopressor®)

May block symptoms of low blood sugar in diabetics on treatment with insulin or an oral diabetes medication.

Corticosteroids (prednisone)

May worsen diabetic control.

Hypertension/high blood pressure

diet pills; amphetamines

May increase blood pressure.

Respiratory or lung diseases, such as asthma, emphysema

beta blockers (Tenormin®, Inderal®, Lopressor®)

May worsen breathing function in persons with respiratory or lung diseases, such as asthma, emphysema, or bronchitis.

sedative/hypnotics (Halcion®, Ambien®, Dalmane®)

May slow breathing in persons with respiratory or lung diseases, such as asthma, emphysema, or bronchitis.

Ulcers

non-steroidal anti-inflammatory medications (ibuprofen, Motrin®, Aleve®)

May worsen ulcer disease and GERD (reflux disease).

Aspirin in doses
above 325 MG

May worsen ulcer disease and GERD (reflux disease).

potassium supplements (all)

May cause stomach irritation with symptoms similar to ulcer disease.

Seizures/Epilepsy

clozapine (Clozaril®)
chlorpromazine (Thorazine®)
thioridazine (Mellaril®)
chlorprothixene (Taractan®)

Make seizures more likely.

Circulation Problems beta blockers (Tenormin®, Inderal®, Lopressor®) May worsen blood flow through small arteries and cause circulation problems
metoclopramide (Reglan®) May worsen blood flow through small arteries and cause circulation problems.
Blood Clotting Disorders
(Only those on blood thinners/anticoagulant therapy)

Aspirin

May cause bleeding in those using blood thinners/anticoagulants.

non-steroidal anti-inflammatory medications (ibuprofen, Motrin®, Aleve®)

May cause bleeding in those using blood thinners/anticoagulants.

dipyridamole (Persantine®)
Ticlopidine (Ticlid®)

May cause bleeding in those using blood thinners/anticoagulants.

Prostate Disease/Benign Prostatic Hyperplasia (BPH)

Antihistamines
chlorpheniramine (Chlor-Trimeton®)
diphenhydramine (Benadryl®)
hydroxyzine (Vistaril®, Atarax®)
cyproheptadine (Periactin®)

May impair urination and cause obstruction in persons with BPH.

stomach and intestinal antispasmodics
dicyclomine (Bentyl®)
hyoscyamine (Levsin®, Levsinex®)
propantheline (Pro-Banthine®)
belladonna alkaloids (Donnatal®)
clidinium/chlordiazepoxide (Librax®)

May impair urination and cause obstruction in persons with BPH.

muscle relaxants
cyclobenzaprine (Flexeril®)
methocarbamol (Robaxin®)
carisoprodol (Soma®)
oxybutynin (Ditropan®);
chlorzoxazone (Paraflex®);
metaxalone (Skelaxin®)

May impair urination and cause obstruction in persons with BPH.

narcotics
propoxyphene and combination products
(Darvon®, Darvocet N-100®)
meperidine (Demerol®)

May impair urination and cause obstruction in persons with BPH.

oxybutynin (Ditropan®)

May impair the ability to urinate in persons with BPH.

urecholine (Bethanechol®)

May impair the ability to urinate in persons with BPH.

certain antidepressants
amitriptyline (Elavil®)
chlordiazepoxide/amitriptyline (Limbitrol®)
perphenazine/amitriptyline
(Triavil®)
doxepin (Sinequan®)

May impair the ability to urinate in persons with BPH.

Incontinence

alpha blockers
Doxazosin (Cardura®)
Prazosin (Minipress®)
Terazosin (Hytrin®)

May cause incontinence by relaxing the bladder.

Constipation

Narcotic pain relievers

Will cause or worsen constipation.

Certain antidepressants
amitriptyline (Elavil®)
chlordiazepoxide/amitriptyline (Limbitrol®)
perphenazine/amitriptyline
(Triavil®)
doxepin (Sinequan®)

May worsen constipation.

Iron products

Will cause or worsen constipation.

Dizziness/Lightheadedness or Falls

beta blockers
(Tenormin®, Inderal®, Lopressor®)

May slow the heart and weakens the pumping action of the heart. May cause dizziness/lightheadedness or falls.

Antianxiety medications
diazepam (Valium®)
flurazepam (Dalmane®)

May contribute to falls due to sleepiness, confusion, and other side effects.

Abnormal heart rhythms/Arrhythmias

tricyclic antidepressants
amitriptyline (Elavil®)
chlordiazepoxide/amitriptyline (Limbitrol®)
perphenazine/amitriptyline
(Triavil®)
doxepin (Sinequan®)

May induce abnormal heart rhythm.

Insomnia

Decongestants (Sudafed®)

May cause or worsen insomnia.

Theophylline (Theodur®)

May cause or worsen insomnia.

Certain antidepressants (Desipramine, SSRIs, MAO Inhibitors)

May cause or worsen insomnia.

beta agonists
albuterol (Proventil®, Ventolin®)

May cause or worsen insomnia.


Adapted from Beers MH, Ouslander JG, Rollinger I, Reuben DB, Brooks J, Beck JC. Explicit criteria for determining inappropriate medication use in nursing home residents. Arch Intern Med 1991; 151:1825-32. and Beers MH. Explicit criteria for determining potentially inappropriate medication use by the elderly: an update. Arch Intern Med 1997; 157:1531-6.

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Always seek the advice of your pharmacist and/or physician before making any changes to your medication regimen. The senior care pharmacists described on this Web site are not endorsed by, or qualified by, the American Society of Consultant Pharmacists or its Research and Education Foundation. Patients, caregivers, professionals, and others using this website should conduct interviews, consult references, and take other appropriate measures to assess the qualifications of senior care pharmacists. The American Society of Consultant Pharmacists and its Research and Education Foundation disclaim any liability in connection with services rendered by a senior care pharmacist described on this Web site.

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